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Gout ( Reading materials ) word


Definition

Gout Is a true crystal deposit   disease(monosodiom urate crystals).it may present as acute arthritis,bursitis,tenosynovitis,cellulitis or tophaceous deposit .

Prolonged hyperuricemias necessary but alone is not enough to develop gout

Types of gout

Primary  gout

Secondary  gout

Etiology

1/3 of body uric acid pool is derrived from diet    2/3 of body uric acid pool is from endogenous purine metabolism.

Elemination of uric acid by the kidney (2/3) and gut (1/3)

Xanthine oxidase enzyme catalyses the end conversation of hypoxanthine to xanthine and to uric acid

 

Risk factorsgout

1- hyperuricemia

2-obesity

3-high alcohol intake

4-hypertension

5- IHD

6-inhereted alteration of tissue factors

Clinical features

1-acute gouty arthritis

2-intercritical

3-Chronic

4-Urolithiasis

Foods helps to protect or  reduce the risk of gout

Foods to be avoided

 INVESTIGATIONS

MSU  crystals  in aspirate

serum  uric acid

24 hour urine uric acid

– blood urea and serum creatinine

fasting lipid profile

-full blood count and ESR

-CRP

-radiograghs

MANAGEMENT

1-  during  THE  ACUTE   ATTACK

2- long term management

Hyperuricemic drug therapy

Allopurinol

The aim of treatment

Uricosuric drugs

Asymptomatic hyperuricemia

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