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Textbook of Nephro-Endocrinology PDF

Textbook of Nephro-Endocrinology PDF

Textbook of Nephro-Endocrinology
 Author Ajay K. Singh MB FRCP and Gordon H. Williams
File size 11 MB
Year 2008
Pages 522
Language English
Category Endocrinology,Neurology
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Book Description:
During the last quarter century, dramatic increases in our understanding of the relationship of the renal and endocrine systems have occurred. While many of these advances have been documented in original and review articles and in some standard medical, renal or endocrine textbooks, a compilation of them in one text has not been available. Of interest, it was 25 years ago in 1983 that Dr. Michael Dunn edited what we believe was the last text on this subject. One of the editors of this text also served as a chapter author in Dunn’s book. Some subjects are similar between Dunn’s and the present text. Both have chapters on the renin–angiotensin system, aldosterone, antidiuretic hormone, parathyroid hormone and Vitamin D, insulin, thyroid hormone, female sex hormones and erythropoietin. In addition, the current textbook has chapters on atrial natriuretic peptides, growth hormone, acid–base balance and pregnancy. During the past quarter century, there have been major increases in the tools needed to understand human physiology and pathophysiology. There has been substantial growth of bench tools, e.g., molecular biology, confocal microscopy and genetic manipulations of mice, available to understand fundamental mechanisms. Likewise there have been advances in the development of clinical tools unheard of 25 years ago, e.g., human genetics, high resolution imaging, advance statistics and bioinformatics. Because of these two facts, what could be written concerning the interaction of a hormone and the kidney in a single chapter 25 years ago now requires an entire section. Thus, instead of single chapters on the Renin–Angiotensin System, Aldosterone, Antidiuretic hormone, and Erythropoietin, the current text has entire sections devoted to these specifi c subjects. Similar to Dunn’s textbook, the current one divides the subject matter into hormones produced by the kidney and hormones that act on the kidney. In addition the current textbook has a section on hormonal derangements and/or effects in individuals with chronic renal insuffi ciency. While the focus is on the actions and effects in humans, individual chapters draw on relevant preclinical data to more clearly understand the effects in humans. Each section begins with an historical introduction to the subject matter and then provides in depth discussions of it in one or more following chapters. The section on hormones and renal insuffi ciency discusses insulin/diabetes, growth hormone, sex steroids, thyroid hormone, acid–base disturbances and pregnancy. There are some subjects they could potential fi t under the umbrella of the theme of this book that are not included. We apologize for any such omissions. However, space and time considerations limited our ability to include them

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