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ISCN 2016 PDF – 1st Edition

ISCN 2016 PDF – 1st Edition


In 1956 Tjio and Levan, in their now classic article, reported that the human chromosome number was 46 and not 48. This work, which was carried out on cultured human embryonic cells, was rapidly confirmed by studies of testicular material by Ford and Hamerton (1956). These two articles stimulated a renewed interest in human cytogeneties, and, by 1959, sev-eral laboratories were engaged in the study of human chromosomes and a variety of classifi-cation and nomenclature systems had been proposed. This resulted in confusion in the lit-erature and a need to establish a common system of nomenclature that would improve com-munication between workers in the field. For this reason, a small study group was convened in Denver. Colorado at the suggestion of Charles E. Ford.

Fourteen investigators and three consultants participated, representing each of the laboratories that had published human karyotypes up to that time. The system proposed in the report of this meeting, entitled “A Proposed Standard System of Nomencla-lure of Human Mitotic Chromosomes,” more commonly known as the Denver Conference (1960). has formed the basis for all subsequent nomenclature reports and has remained virtu-ally unaltered. despite the rapid developments of the last 25 years. It is fair to say that the participants at Denver did their job so well that this report has formed the cornerstone of hu-man cytogenetics since 1960. and the foresight and cooperation shown by these investigators have prevented much of the nomenclature confusion which has marked other areas of human genetics.

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