Every Day One Disease

Every day one disease Smoker’s Melanosis PDF


Smoker’s Melanosis
Definition : Smoker’s melanosis, or smoking-associated melanosis, is a benign abnormal melanin pigmentation of the oral mucosa.
Etiology : Tobacco smoke that stimulates melanocytes.
Clinical features:  Clinically, it appears as multiple brown pigmented areas, usually located on the anterior labial gingiva of the mandible (Fig. 85). Pigmentation of the buccal mucosa and palate has been asso­ciated with pipe smoking. The intensity of pigmentation is related to time and dose. Women are more commonly affected.
Differential diagnosis: Normal pigmentation, drug-induced pigmentation, pigmented nevi, melanoma, Addison disease.
 
Treatment : No treatment is required. Cessation of smoking is usually associated with a return of normal mucosal pigmentation.
 
Every day one disease Smoker’s Melanosis
 

Smoker’s melanosis is seen with the naked eye as a brown to black pigmentation of the oral tissue i.e. the gums,[1] cheeks or palate [2] as well as in larynx.[3][4] It is most often seen in the lower labial gingiva of tobacco users. Most easily it is found in Caucasians, due to their lack of a genetically caused melanin pigmentation.[5]

The brown to black colour is melanin. In skin, melanin prevents harmful UV-light from reaching deeper, sensible parts of the tissue. If UV-light penetrates deep, some of the toxic substances due to the UV-light damage to the cells, are bound to melanin in the epithelial cells and travel with the ageing cells to the skin surface, where they are expelled from the tissue surface. In this way the melanocytes and kerationocytes together protect the tissue with melanin serving as a toxic defence- and cleaning agent.

In the oral mucosa, where the ageing epithelial cells move faster to the surface compared to skin, a similar defence-mechanism seems to be present, but here acting to clean the mucosa from different toxic chemicals entering the mouth. Besides chemicals in tobacco also antimalaria-drugs cause an oral pigmentation. Smoker’s melanosis is like the genetic melanin pigmentations a defence-system in action.

The microscope shows smoker’s melanosis to be characterized by a melanin hyperpigmentation of the lower part of the oral epithelium, similar to sun-tanned skin. The hyperpigmentation consists of melanin granules which have the shape and colour of “coffea beans”. They are produced by the dendritic, octopus-like melanocytes, seen between the epithelial cells situated closest to the epithelium/connective tissue border.[6]

In tobacco-users the melanocytes are stimulated to produce melanin granules and to distribute them out to the surrounding epithelial cells for further transport to the mucosal surface, like the mechanism in melanin-pigmented skin.

Small amounts of melanin-like granules together with other electrone-dense particles can also be seen within large melanosome complexes in the underlying connective tissue.[7] If the granules derive from the epithelium, a phenomenon known as melanin incontinence, is not known.[8] In Caucasians these granules are not expected to influence on the clinically observed degree of smoker’s melanosis.