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Greenspan’s Basic and Clinical Endocrinology 9th Edition

Greenspan’s Basic and Clinical Endocrinology 9th Edition PDF

Greenspan’s Basic and Clinical Endocrinology 9th Edition PDF


This represenrs rhe nimh edirion of Greenspan’s Basic & Clinical Endocrinology-rhe firsr in an all-color formar, which we hope will add ro rhe value of rhe rexr for our readers. Each of rhe individual chaprers has been revised and updared ro conrain rhe mosr currenr informarion in rhe field. We have inrroduced rwo enrirely new chaprers on Endocrine Hyperrension (Chaprer 1 0) and Obesiry (Chaprer 20) and added five new aurhors ro our exisring chaprers. Once again, we hope rhar you will find rhis rexr useful in dealing wirh rhe expanding world of basic and clinical endocrinology, and we rrusr rhar you will find ir a valuable roo] for educarion of trainees and rhe rrearmenr of endocrine pariems. Hormones are signaling molecules that traffic information from one cell tO another, typically through a soluble medium like the extracellular fluid. Hormones fall inro one of a number of different hormonal classes (eg, steroids, monoamines, peptides, proteins, eicosanoids) and signal through a variety of general (eg, nuclear vs cell surface) and specific (eg, tyrosine kinase vs phosphoinositide turnover) mechanisms in target cells.
Hormones produced in one tissue may promote activity in a target tissue at some distance from the point of secretion. In this case the hormone travels through the bloodstream, often bound ro a plasma protein, tO access the target tissue. In addition, hormones may act locally following secretion; either on a neighboring cell (paracrine effect), on the secretary cell itself (aurocrine effect), or without actually being released from the secretory cell (intracrine effect) (Figure 1 – 1 ) . Identification o f a tissue as a target for a particular hormone requires the presence of receptOrs for the hormone in cells of the target tissue. These receprors, in turn, are linked tO effector mechanisms that lead tO the physiological effects associated with the hormone.