Histology Pathology

Lever’s Histopathology of the Skin 11th Edition PDF

Lever’s Histopathology of the Skin 11th Edition PDF

Lever’s Histopathology of the Skin 11th Edition PDF


This book represents an incremental revision and update of the previous three editions, the first of which constituted a somewhat more extensive revision of the seven editions produced by Walter Lever, MD, beginning in 1949 as a 449 page volume with “221 Illustrations Including 8 Subjects in Color on 4 Plates.” Thus, this will be the 11th edition of a book that has been continuously published for more than 65 years! In this second generation of the work, the principles that made “Lever” such a success for so long continue to be applied, and are extended in this edition. These include, first and foremost, a continued organization of the book along the lines of a traditional clinicopathologic classification of cutaneous disease. This enables us to discuss lesions according to their clinical and etiological relationships, paralleling the organization of the major clinical texts. In some other dermatopathology works, a greater emphasis has been placed on histological patterns of disease as the underpinning of the chapter organization. This has advantages in enabling beginners to develop an appropriate differential diagnosis for a given pattern of disease, but can be confusing in that etiologically and clinically disparate conditions tend to be discussed in juxtaposition to each other, and also in that polymorphous conditions need to be discussed in multiple different places.

We have taken into account the modern emphasis on pattern recognition in several ways. First, within each chapter, the conditions considered are, when appropriate, organized and discussed along pattern lines. Second, we have, as in the past, included a chapter that presents an algorithmic classification of skin diseases according to histologic pattern features. It is intended that this chapter may serve as a means of developing a differential diagnosis from an unknown slide, following which page references are provided to discussion of the disorders in other areas of the book. In addition, we have prepared a companion volume Synopsis and Atlas of Lever’s Histopathology of the Skin, now in its third edition. This Atlas has enabled us to greatly extend the number of illustrations including a larger number of clinical images, and is organized completely on the basis of histologic patterns. Unlike some other pattern based works, this Atlas includes neoplastic disorders among the inflammatory conditions. Thus, it becomes clear to the reader that a lichenoid actinic keratosis or in situ melanoma may share features with (and potentially be misdiagnosed as) a plaque of lichen planus or a patch of lupus. This Atlas will continue to be updated and extended to incorporate the new information in successive editions of the “Big Lever.”


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