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Randomized Clinical Trials of Nonpharmacological Treatments

Randomized Clinical Trials of Nonpharmacological Treatments PDF

Randomized Clinical Trials of Nonpharmacological Treatments PDF
Author Isabelle Boutron
File size 5.08 MB
Year 2011
Pages 403
Language English
File format PDF
Category
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Book Description

Nonpharmacological treatments include a wide variety of treatments such as surgery technical procedures implantable and non-implantable devices rehabilitation psychotherapy and behavioral interventions. Unlike pharmacological treatments these have no specific requirements for approval. Consequently they can be widely proposed in clinical practice but may not have been adequately evaluated. This situation is an important barrier for the evaluation of the beneficial effects of these treatments and the conduct of clinical trials. Randomized Clinical Trials of Nonpharmacologic Treatments focuses on the methods for assessing nonpharmacological treatments highlighting specific issues and trial design.

Features:

  • Chapters written by international experts in the field
  • Highlights specific issues in assessing nonpharmacological treatments in trials including:
    • how to overcome the difficulties of blinding patients care providers and outcome assessors
    • the complexity of the intervention the learning curve and the clustering effect
    • placebos that can be used
    • issues of assessing harm and assessing the applicability of trials
  • Presents a variety of trial designs for nonpharmacological treatments―including cluster randomized controlled trials expertise-based trials pragmatic trials and nonrandomized trials.
  • Provides several examples of the planning conduct analyses and reporting of trials in different fields including surgery technical interventions medical devices rehabilitation psychotherapy and behavioral interventions.

Providing practical examples that underline these issues and solutions this book is one of the first to exclusively explore this topic discussing various categories of treatments from surgical procedures to psychotherapy.

Randomized Clinical Trials of Nonpharmacological Treatments PDF Randomized Clinical Trials of Nonpharmacological Treatments PDF Free Download Randomized Clinical Trials of Nonpharmacological Treatments PDF Ebook