Cancer Cell Signaling

Cancer Cell Signaling PDF

Cancer Cell Signaling PDF


The discovery of tumor suppressor genes, whose loss predisposes to tumor
development, has revolutionized the molecular analysis of cancer (1–3). By definition,
tumor suppressor genes are genetically linked to a cancer. For example,
the retinoblastoma (RB) tumor suppressor was first identified as a gene that
was specifically lost in familial RB (4–6). The majority of tumor suppressors has been identified based on linkage analysis and subsequent epidemiological
studies, however, initial understanding of their mode of action was relatively
limited. As the number of tumor suppressors has increased, understanding the
mechanism through which tumor suppressors function has become an important
aspect of cancer biology.

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