Enzyme Inhibition in Drug Discovery and Development

Enzyme Inhibition in Drug Discovery and Development PDF

Enzyme Inhibition in Drug Discovery and Development PDF
Preface

Preface:

The science and applied approaches of enzyme inhibition in drugdiscovery and development

Offering a unique approach that includes both the pharmacologicand pharmaco-kinetic aspects of enzyme inhibition, EnzymeInhibition in Drug Discovery and Development examines thescientific concepts and experimental approaches related to enzymeinhibition as applied in drug discovery and drug development.

With chapters written by over fifty leading experts in theirfields, Enzyme Inhibition in Drug Discovery and Developmentfosters a cross-fertilization of pharmacology, drug metabolism,pharmacokinetics, and toxicology by understanding the “good”inhibitions—desirable pharmacological effects—and “bad”inhibitions—drug–drug interactions and toxicity. Thebook discusses:

  • The drug discovery process, including drug discovery strategy,medicinal chemistry, analytical chemistry, drug metabolism,pharmacokinetics, and safety biomarker assessment

  • The manipulations of drug metabolizing enzymes and transportersas well as the negative consequences, such as drug–druginteractions

  • The inhibition of several major drug target pathways, such asthe GPCR pathway, the NFkB pathway, and the ion channel pathway

Through this focused, single-source reference on thefundamentals of drug discovery and development, researchers in drugmetabolism and pharmacokinetics (DMPK) will learn and appreciatetarget biology in drug discovery; discovery biologists andmedicinal chemists will also broaden their understanding ofDMPK.

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