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Modeling of electrophysiology and tension development in the human heart

Modeling of electrophysiology and tension development in the human heart

Modeling of electrophysiology and tension development in the human heart PDF

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Modeling of electrophysiology and tension development in the human heart PDF

Preface

The modeling of cardiac electromechanics includes several different research topics i.e. anatomy electrophysiology conduction and tension development. To achieve quantitative simulations new models were developed and existing models were enhanced. A main objective is to reconstruct human electromechanical heterogeneity in schematic and realistic anatomies. Modeling of heterogeneous electrophysiology is achieved by incorporating measurement data of different regions. The fiber orientations are inserted with rule-based methods. Furthermore several different pathological states were modeled. A special focus is given on atrial and ventricular arrhythmia electrophysiological remodeling due to AF and genetic defects like the long QT syndrome. The results help to gain new insights into the heart’s function and to support the understanding of pathologies. Furthermore the effects of drugs can be inserted in the model in order to investigate the effects of these drugs on human electrophysiology even in early development state.