The Metabolic-psychosomatic Axis Stress and Oxytocin Regulation
The brain capillary glucose uptake by red-cells leads to the endogenous generation of 23-DPG and promotes the oxyHb-deoxygenation to discharge Mg2+ at the noradrenergic synapses.
Since adrenaline cannot cross the blood brain barrier it could not have a feedback; however cortisol does.
cAMP controls the activation of the initial voltage-gated state of the action potential configuring nerve impulse transcription-plasticity mechanism and long-term memory.
Overall this molecular mechanism could be used to propose a model linking environmental stimulus resulting in cAMP and the rate of gene expression.
DNA-dependent RNA polymerase activation is inducible expressed under the conditions of adaptive value by cAMP. The zipper-closure role of the enzyme functions with divalent metal for inclusion of the cyclic nucleotide cAMP and cGMP in DNA. cAMP by binding to Mg2+ ion interacts with the negatively charged phosphate groups. The latter chelated by Mg2+ opens the double chain in DNA for binding DNA-dependent RNA polymerase. The greater activity of cAMP-Me2+-DNA complex with regard to a stabilized double helix allows for the introduction of a mechanism for genetic induction vs constitutive state.
The cAMP-Me2+-DNA complex by increasing a turn-on activity could consolidate cAMP stimulus allowing genetic variance by insertion of cAMP by adhesion of cAMP to stimulate a similar area of the DNA at different stages on the overall evolutionary/adaptive response to environmental stress.