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Gentamicin Biosynthesis Medicinal Applications and Potential Side Effects PDF


Gentamicin Biosynthesis Medicinal Applications and Potential Side Effects PDF

Gentamicin Biosynthesis Medicinal Applications and Potential Side Effects
 Author Emilie Kruger
File size 1.88 MB
Year 2013
Pages 133
Language English
PDF
Category Free Medical Books

Book Description:
Gentamicin is an aminoglycoside antibiotic naturally synthesized by Micromonospora, a Gram-positive genus of bacteria widely found in water and soil. This antibiotic is useful against a wide variety of bacteria, and works by binding the 30S subunit of the bacterial ribosome, which interrupts bacterial protein synthesis. In this book, the authors discuss the biosynthesis, medicinal applications and potential side effects of Gentamicin. Topics include Gentamicin used in combination therapy and applied to medicinal materials for clinical applications; use of natural products to enhance the antibiotic activity of Gentamicin and other aminoglycosides; regiospecific Gentamicin functionalization; Gentamicin and particle engineering; and the indications and adverse effects of Gentamicin. Chapter 1 – Gentamicin (GM) was discovered in 1963 and was introduced into parenteral usage in 1971. Since then, GM has been widely used in medicinal applications. The Food and Drug Administration (FDA) of the United States approved the routine prescription of GM to treat the following infectious disorders: infection due to Klebsiella pneumoniae, Escherichia coli, Serratia marcescens, Citrobacter spp., Enterobacteriaceae spp., Pseudomonas spp.; Staphylococcus infectious disease; bacterial meningitis; bacterial sepsis of newborns; bacterial septicemia; infection of the eye, bone, skin and/or subcutaneous tissue; infective endocarditis; peritoneal dialysis–associated peritonitis due to Pseudomonas and other gram-negative organisms; peritonitis due to gastrointestinal tract infections; respiratory tract infections; and urinary tract infectious disease. GM is an old antibiotic and is used widely beyond its FDA-labeled indications as follows: actinomycotic infection; Staph. saprophyticus bacteremia with pyelonephritis; appendicitis; cystic fibrosis; diverticulitis;

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