Anticancer Agents from Natural Products Second Edition PDF Free Download
|Author||Gordon M. Cragg|
|File size||47.8 MB|
|Category||Free Medical Books|
[box title=”Disclaimer“] This Website complies with DMCA Digital Copyright Laws.Please bear in mind that we do not own copyrights to this book/software. We’re sharing this with our audience ONLY for educational purpose and we highly encourage our visitors to purchase original licensed software/Books. If someone with copyrights wants us to remove this software/Book please contact us. immediately.
You may send an email to firstname.lastname@example.org for all DMCA / Removal Requests.
The approach to drug discovery from natural sources has yielded many important new pharmaceuticals inaccessible by other routes. In many cases the isolated natural product may not be an effective drug for any of several reasons but it nevertheless may become a drug through chemical modification or have a novel pharmacophore for future drug design. In summarizing the status of natural products as cancer chemotherapeutics Anticancer Agents from Natural Products Second Edition covers the:
- History of each covered drug―a discussion of its mechanism on action medicinal chemistry synthesis and clinical applications
- Potential for novel drug discovery through the use of genome mining as well as future developments in anticancer drug discovery
- Important biosynthetic approaches to “unnatural” natural products
Anticancer Agents from Natural Products Second Edition discusses how complex target-oriented synthesis―enabled by historic advances in methodology―has enormously expanded the scope of the possible. This book covers the current clinically used anticancer agents that are either natural products or are clearly derived from natural product leads. It also reviews drug candidates currently in clinical development since many of these will be clinically used drugs in the future.
Examples include the drugs etoposide and teniposide derived from the lead compound podophyllotoxin; numerous analogs derived from taxol; topotecan derived from camptothecin; and the synthetic clinical candidates E7389 and HTI-286 developed from the marine leads halichondrin B and hemiasterlin.
Anticancer Agents from Natural Products Second Edition PDF Anticancer Agents from Natural Products Second Edition Free Download Anticancer Agents from Natural Products Second Edition Ebook