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Atlas of Clinical Neurology 3rd Edition PDF

Atlas of Clinical Neurology 3rd Edition PDF Free Download
Atlas of Clinical Neurology 3rd Edition PDF
Preface:

The third edition of the Atlas of Clinical Neurology highlights and underscores the enormous strides being made in the biologic understanding of neurologic disease. Neurology is a highly visual specialty. The neurologic examination, MRI, electroencephalography, PET, functional MRI, and light and electron microscopy are examples of visual images that define neurologic disease and normal brain functions. This atlas has been designed to provide a comprehensive visual exposition and integration of all aspects of neurologic disease, including clinical syndromes and related neuropathology, neuroradiology, neurophysiology, neuropharmacology, neurochemistry, and molecular biology. The goal is to provide a holistic visual concept of neurologic disease to provide the clinician with an overall image of a specific neurologic disorder. Quality patient management requires the good judgment and factual knowledge of an experienced physician. The Atlas of Clinical Neurology is intended to provide essential information about neurologic disease in an immediate and integrated manner to facilitate the neurologist in the primary function of providing excellence in patient care. There has been great progress in the past decade in our understanding of the cellular and molecular basis of many neurologic diseases. As a result, each chapter has been revised and updated to reflect these advances. New therapies have been developed as a result of this recent knowledge. Thrombolytic therapy for stroke, deep brain stimulation for Parkinson’s disease, new classes of anti-convulsants, and effective immune therapy for multiple sclerosis represent examples of recent significant therapeutic advances in neurology. Of great importance to the understanding of gene structure and function in the nervous system has been the discovery of DNA triplet repeat expansions in autosomal dominant neurogenetic diseases, including Huntington’s disease, olivopontocerebellar atrophy (SCA1), Machado-Joseph disease, dentatorubropallidoluysian atrophy, fragile-X disease, myotonic muscular dystrophy, and Friedreich’s ataxia. The leading cause of dementia in our society, Alzheimer’s disease (AD), affecting over 4 million Americans and countless millions more around the world, has been shown to be a clinical syndrome due to specific genetic mutations in selected families with dominantly inherited disease. Mutations in the amyloid precursor protein gene (chromosome 21), the presenilin 1 gene (chromosome 14), and the presenilin 2 gene (chromosome 1) result in dominantly inherited AD. A major risk factor for AD is the presence of the E4 allele of apoliopoprotein E (chromosome 19). Additional detailed images related to the dementias are included in the third edition of the atlas. These clinical–molecular correlations are all very recent and attest to the scientific vigor of current neruoscientific research. It is my view that in the near future these data will lead to effective new therapies for AD that will slow its rate of progress and significantly reduce the incidence of this major, debilitating disease. PET and functional MRI have effectively defined regional brain areas for behaviors. The clarity of insights into heterogeneous brain function by PET and MRI is literally revolutionizing our concept of how our brains think.

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