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Basic Pharmacokinetics 2nd Edition PDF

Basic Pharmacokinetics 2nd Edition PDF Free Download
Basic Pharmacokinetics 2nd Edition PDF
Preface:

Pharmacokinetics and biopharmaceutics courses have been included in pharmacy curricula across the United States and in many other countries for the past several years. At present, there are a number of textbooks available for use by students and other readers. Most of these textbooks, although valuable and well written, concentrate on presenting the material in substantial mathematical depth, with much less needed emphasis on explanations which will facilitate understanding and the ability to use the pharmacokinetic equations that are introduced. Furthermore, also evident in currently available textbooks is a paucity of adequate explanation regarding factors influencing pharmacokinetic parameters present in these equations. The intent of this textbook is to provide the reader with a basic intuitive understanding of the principles of pharmacokinetics and biopharmaceutics and how these principles, along with the equations presented in each chapter, can be applied to achieve successful drug therapy. It has been our intent to illustrate the application of pharmacokinetic principles and equations by providing the reader with data available in the literature. Additionally, when relevant, problem sets and problem-solving exercises, complete with keys, have been provided at the conclusion of each chapter. This approach will enable the reader to become adept at solving pharmacokinetic problems arising in drug therapy and to understand the applications and utility of equations in clinical practice. Since pharmacokinetics is basically mathematical in nature, a chapter has been included to provide the reader with a basic review of the mathematical principles and graphing techniques necessary to understand pharmacokinetics. At the outset of each chapter, important objectives have been listed that will accentuate and identify the salient and indelible points of the chapter. When an important and clinically applicable equation appears in the text, a paragraph follows explaining the significance and therapeutic applications of the equation. Additionally, this paragraph includes and explains the relevant factors which influence the parameters appearing in an equation. After the introduction of an important equation, a general profile illustrating the relationship between the two variables of an equation has been presented. This approach, we believe, will demystify key concepts in pharmacokinetics. Derivations of key equations have been included to show their origins and to satisfy the inquisitive student. However, the student is not required to memorize any of these derivations or to be able to perform them in any problem set or problem solving exercise.

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