Cancer Imaging Lung and Breast Carcinomas Volume 1 PDF Free Download
The primary objective of this series, CANCER IMAGING, is to present the readers with the most up-to-date instrumentation, general applications, as well as specific applications of imaging technology to diagnose various cancers. The present work concentrates on the application of this technology to the diagnosis of lung and breast carcinomas, the two major worldwide cancers. In this work we discuss strategies for imaging cancer and clinical applications of this technology and explain the role of molecular imaging in early therapy monitoring. In addition, we cover the following topics: synthesis and use of different contrast agents, especially the most commonly used tracer, 18F-fluorodeoxyglucose (FDG), in conjunction with imaging modalities (e.g., magnetic resonance imaging [MRI]); the advantages and limitations of the tracers; and rational and protocol details of whole-body screening with computed tomography (CT), positron emission tomography (PET), and PET/CT. We also describe the role of imaging in drug development, gene therapy, and therapy with monoclonal antibodies; for example, we describe the advantages of preclinical immuno-PET. The advantages of hybrid modalities, such as PET/CT (e.g., in lung cancer), are also presented. The importance of the use of imaging for clinical diagnosis is presented in detail, and the relationship between radiation dose and image quality is discussed. In addition, we present detailed methods for absorbed X-ray dose measurement in mammography to avoid the risk of radiation-induced carcinogenesis. We also detail lung cancer screening, staging, and diagnosing, applying different imaging modalities and point out false-negative and false-positive images potentially encountered in various body parts when imaged. Imaging modalities, including high-resolution CT, thinsection CT, computer-aided diagnosis with CT, low-dose helical CT, and FDG-PET/CT, used for staging and diagnosing lung cancer (e.g., non-small cell lung carcinoma), are discussed. Details of a large number of imaging modalities, including optical mammography, digital mammography, contrast-enhanced MRI, SPECT, color-Doppler sonography, and sonography, used for diagnosing breast cancer are presented. Other topics include use of imaging for diagnosing invasive lobular carcinoma, density of breast carcinoma, axillary lymph node status in breast cancer, small-size primary breast cancer, and microcalcification in breast lesions.