General and Oral Pathology for Dental Hygiene Practice is an introductory textbook written for dental hygiene students studying general and oral pathology, and as a resource for dental educators and clinicians. Our career journeys have included training and clinical practice in dental assisting, dental hygiene, dentistry, and oral and maxillofacial pathology. We have more than 76 years combined experience in dentistry, oral and maxillofacial pathology, and dental education. Throughout the years we have received numerous requests to write a pathology textbook targeting dental hygiene that contains current material contributed from experts in their respective fields. This inspired us to write such a text that is also student-oriented, instructor- friendly, and includes online supplementary materials. General and Oral Pathology for Dental Hygiene Practice is a direct result of our combined passion for dental hygiene education, dentistry, and oral pathology. Our goal is to use educational tools that promote critical thinking and transfer learning outcomes to clinical dental hygiene practice. Approach First, we understand that not everyone who teaches pathology in the dental hygiene curriculum has advanced training in general and oral pathology. Our textbook seeks to “train the trainer” by use of supplementary materials. These instructor resources not only enhance student learning but also promote instructor confidence in the material. Second, our colleagues in dental hygiene education report that currently available texts often do not provide a sufficient depth of background knowledge important for understanding and assessing pathology. For instance, oral lesions associated with systemic conditions are described, but essential discussion of the underlying disease mechanism may be sparse or missing. Additionally, etiologies and risk factors for diseases are not consistently emphasized. To address this issue, we begin each chapter with concise foundational and basic principles of pathology related to disorders or lesions presented in the chapter. The effects of disease processes on the oral cavity and human body are emphasized as they relate to clinical practice.