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Handbook of Safety Assessment of Nanomaterials PDF

Handbook of Safety Assessment of Nanomaterials PDF Free Download

Handbook of Safety Assessment of Nanomaterials PDF
Author Bengt Fadeel
File size 13.1 MB
Year 2014
Pages 562
Language English
File format PDF
Category
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Book Description

The rapidly evolving field of nanomedicine refers to the clinical application of nanotechnologies. However as with all new technologies there are ethical safety and regulatory issues. This handbook written by leading international experts provides a meticulous overview of the state of the art of safety assessment of nanomaterials (nanotoxicology) in the context of their application in nanomedicine.

The volume includes a historical perspective on the development of nanomedicine and its regulation and a personal view of the future of (nano)medicine by Patrick Hunziker president of the European Society of Nanomedicine. Ethical considerations in relation to nanomedicine are discussed. There are a series of chapters on organ-specific toxicities of nanomaterials including pulmonary and cardiovascular toxicity neurotoxicity dermatotoxicity and reproductive toxicity as well as a discussion on immunotoxicity and genotoxicity. The importance of a thorough characterization of physicochemical properties of nanomaterials is emphasized. The handbook also contains a critical discussion on the applicability of in vitro versus in vivo methods and models for nanosafety assessment along with an introduction to mathematical modeling approaches with a view to a predictive toxicology of nanomaterials. The overall aim is to provide a comprehensive science-based framework for safety assessment of current and future nanomedicines.

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