consult the original literature. For many compounds the number of analytical procedures is so large that it is not possible to fully abstract all of them. For this reason we have added annotated bibliographies so that the researcher can rapidly identify a relevant paper without having to locate and evaluate a large number of irrelevant procedures. In addition to the analytical matrix, other factors may be important when choosing an analytical procedure. Accordingly, we have noted other features of analytical procedures such as sensitivity, mode of detection, other compounds that interfere with the analysis, and other drugs that may be determined at the same time. We would like to thank the staff of the NCI-Frederick Cancer Research and Development Center Scientific Library for their help with this project. In particular, we would like to thank Pat Kuhns-Kelly for her diligent assistance with the computer searches and Ethel Armstrong for her indefatigable efforts in obtaining many of the more obscure references via Interlibrary Loan. The use of the NIH Library, National Institutes of Health, Bethesda, MD, is also greatly appreciated. We would also like to thank Perry King of John Wiley for help with the electronic version.
Special thanks are due to our editor, Betty Sun, who brought the whole project together. The initial research which later became the nucleus of this book was supported by the Division of Safety, NIH, through NCI contract NO1-CO-74102 with Program Resources, Inc. Although many people have helped with the preparation of this work, the mistakes are our own. We would appreciate hearing from anyone who has corrections, comments, or suggestions. We can be reached at email@example.com or firstname.lastname@example.org. The content of this publication does not necessarily reflect the views, policies, or guidelines of the Department of Health and Human Services or the Food and Drug Administration, nor does mention of trade names, commercial products, or organizations imply endorsement by the U.S. Government.