Modern Techniques for Pathogen Detection PDF Free Download
This book gives a comprehensive overview of the frontline research in pathogen detection. Infectious diseases caused by bacterial, viral, or fungal pathogens are one of the leading causes of death worldwide. In order to find the optimal treatment regime for the highly heterogeneous group of patients and to significantly reduce costs in medical care, novel tools that characterize the pathogenic microbes and the host-specific immune response are highly desired. Information about the phenotype and genotype of the germs help to accelerate quick and effective interventions, for example, the treatment of a sepsis patient with the rightmedication. Especially, within this context, the terms personalizedmedicine and pharmacogenomics, which define a stratified treatment for each individual patient, are of increasing importance. Due to a high variety in the responses of a patient panel to similar drug treatment regimes, which are caused by genetic and/or physiological variations among patients, the therapy has to be adapted to achieve highest efficiency and lowest side effects. A plethora of analytical methods such as spanning microbiology, biochemistry, molecular biology, immunology, and biophysics are commonly applied for the detection of pathogens. Modern Techniques for Pathogen Detection informs in detail about various cutting-edge tools for pathogen identification. International scientists of the respective areas highlight recent emerging methods as well as improvements of conventional assays within individual chapters. Themanagement of life-threatening infections, especially sepsis, is covered, due to its importance, in a separate chapter of the book (Chapter 1). In the case of a sepsis suspicion, pathogen detection and administration of the appropriate drug combination should be performed as soon as possible.We stand at the beginning of a more personalized approach toward sepsis care. The novel developed analytical tools can facilitate an early and precise diagnosis of the pathogenic causatives of the severe infection concomitant, with profiling of their genetic status in terms of resistance to a certain antimicrobial therapy and finally also the monitoring of the treatment response.
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