Toxicological Testing Handbook 2nd Edition PDF Free Download: Principles, Applications and Data Interpretation
It addresses such issues as species selection, dose level and dosing regimen, animal number, routes of exposure, and proper statistical evaluation. Chapters focused on particular subdisciplines examine the purpose of the study, choice of species and the conditions under which the animals are maintained, experimental design, route of exposure, the duration of the study, choice of vehicles, and endpoints evaluated. This second edition updates each chapter, with particular efforts made to add more help in data interpretation and hazard assessment. New chapters have been added to reflect changing regulatory requirements. These include chapters on safety pharmacology, juvenile studies, health safety assessment of pharmaceuticals, and heath assessment strategies in the food and cosmetic industry. We have also included a separate and expanded chapter on carcinogenicity studies and the “good laboratory practices” chapter contains new information on how to evaluate the quality of a contract research organization prior to study placement. The current business environment is dominated by downsized workforces, consolidated corporate functions, and lean start-ups. Often companies have a single individual responsible for all regulatory compliance issues. If that person has a background in toxicology at all, it is often general and cursory.